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KMID : 1101220010330020169
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2001 Volume.33 No. 2 p.169 ~ p.176
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Comparison of Liver Function Test with Serum AFP, CEA Abnormal in Health Screening
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You Soo-Woo
Lee Kwang-Keun
Park Hyo-Soon
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Abstract
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Background : Authors investigated the abnonnal rates for serum AFP and CEA among the subjects on health screening tests in Kangbuk Samsung Hospital from March, 2000 to October, 2000. And the liver function test results were analyzed in patients with abnormal serum AFP and CEA. Primary study subjects were 47,042 (male; 28,633, female; 18,409) for serum AFP and 37,847 (male; 23,052, female; 14,795) for serum CEA. Methods : Serum specimen from the subjects were analyzed with two-site sandwich immunoassay using ADVIA Centaur instrument (Bayer Corporation, USA). Results : The abnonnal rate for serum AFP was 0.60% (280/47,042) and that of serum CEA was 0.41 % (1 55/37,847). There were no significant six-differences in abnormal rates for serum AFP and serum CEA; male population showed higher abnormal rate (0.65%) for AFP than female (0.51 %) (p=0.056); male also showed higher abnormal rate (0.47%) for CEA than in female (0.31 %) (p=0.016). Among patients with abnonnal test results, the serum AFP level was 77.8±660.8 ng/mL and their level of GOT level were 44.5±77.6 IU/L, GPT 55.0±134.9 IU/L, ALP 175.1±61.2 IU/L, r -GTP 42.6±113.8 IU/L respectively. The serum CEA level was 6.3±4.6 ng/mL and their level of GOT 26.0±14.9 IU/L, GPT 31.2±27.5 IU/L, ALP 172.6±45.4 IU/L, r -GTP 31.3±36.2 IU/L respectively. Conclusions : There were no significant positive or negative relationship among chemical tests for liver function and tumor markers of AFP and CEA, and therefore the prudence should be applied when interpreting these test results.
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KEYWORD
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Two-site sandwich immunoassay, AFP, CEA, GOT, GPT, ALP, r-GTP
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